Leukoensefalopati multifokal progresif

Leukoensefalopati multifokal progresif atau progressive multifocal leukoencephalopathy (PML), juga dikenal sebagai leukoensefalitis multifokal progresif, adalah penyakit yang jarang dan fatal yang disebabkan oleh virus. Penyakit ini dikarakterisasikan sebagai kerusakan progresif atau peradangan pada massa putih otak pada dua lokasi. Penyakit ini biasanya muncul pada orang yang sistem kekebalan tubuhnya kurang, contohnya pasien yang terinfeksi HIV.

Daftar pustaka

  • Aksamit, A. J. (2001) Treatment of non-AIDS progressive multifocal leukoencephalopathy with cytosin arabinoside. J Neurovirol 2001;7:386.
  • Berger, J.R. (2003) Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. Journal of Neurovirology 9 (supplement), 38-41. PMID 12709870
  • Langer-Gould, A., Atlas, S. W., Bollen, A. W., Pelletier, D. (2005) Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab. N Engl J Med 2005;353:375-81.
  • Vendrely, A., Bienvenu, B., Gasnault, J., Thiebault, J.B., Salmon, D. and Gray, F. (2005) Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDS-related progressive multifocal leukoencephalopathy. Acta Neuropathologica 109, 449-455. PMID 15739098
  • Wyen, C., Hoffmann, C., Schmeisser, N., Wohrmann, A., Qurishi, N., Rockstroh, J., Esser, S., Rieke, A., Ross, B., Lorenzen, T., Schmitz, K., Stenzel, W., Salzberger, B. and Fatkenheuer, G. (2004) Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death. Journal of Acquired Immune Deficiency Syndrome 37, 1263-1268. PMID 15385733

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