Interferon tipe I

Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Interferon Tipe I (α/β/δ…)
Interferon Tipe I (α/β/δ…)
	Struktur molekul interferon-beta manusia (PDB: 1AU1).
Identifikasi
Simbol	Interferon
Pfam	PF00143
InterPro	IPR000471
SMART	SM00076
PROSITE	PDOC00225
SCOP	1au1
SUPERFAMILY	1au1
Pfam
Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Interferon (IFN) tipe I manusia adalah subkelompok besar protein interferon yang membantu mengatur aktivitas sistem kekebalan tubuh.

Interferon mengikat reseptor sitokin tipe II. Semua IFN tipe I mengikat kompleks reseptor permukaan sel tertentu yang disebut reseptor IFN-α (IFNAR), terdiri dari rantai IFNAR1 dan IFNAR2.

IFN tipe I ditemukan pada semua mamalia dan molekul homolog (serupa) telah ditemukan pada burung, reptil, amfibi, serta spesies ikan.^[1]^[2]

Jenis mamalia

Pengelompokan untuk jenis mamalia dinamakan: IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta), IFN-ε (epsilon), IFN-τ (tau), IFN-ω (omega), dan IFN-ζ (zeta, disebut juga limitin).^[3]^[4]

Referensi

^ Schultz U, Kaspers B, Staeheli P (May 2004). "The interferon system of non-mammalian vertebrates". Developmental and Comparative Immunology. 28 (5): 499–508. doi:10.1016/j.dci.2003.09.009. PMID 15062646.
^ Samarajiwa SA, Wilson W, Hertzog PJ (2006). "Type I interferons: genetics and structure". Dalam Meager A. The interferons: characterization and application. Weinheim: Wiley-VCH. hlm. 3–34. ISBN 978-3-527-31180-4.
^ Oritani K, Tomiyama Y (November 2004). "Interferon-zeta/limitin: novel type I interferon that displays a narrow range of biological activity". International Journal of Hematology. 80 (4): 325–31. doi:10.1532/ijh97.04087. PMID 15615256.
^ Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (August 2004). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.

[pmid15062646-1] Schultz U, Kaspers B, Staeheli P (May 2004). "The interferon system of non-mammalian vertebrates". Developmental and Comparative Immunology. 28 (5): 499–508. doi:10.1016/j.dci.2003.09.009. PMID 15062646.

[2] Samarajiwa SA, Wilson W, Hertzog PJ (2006). "Type I interferons: genetics and structure". Dalam Meager A. The interferons: characterization and application. Weinheim: Wiley-VCH. hlm. 3–34. ISBN 978-3-527-31180-4.

[pmid15615256-3] Oritani K, Tomiyama Y (November 2004). "Interferon-zeta/limitin: novel type I interferon that displays a narrow range of biological activity". International Journal of Hematology. 80 (4): 325–31. doi:10.1532/ijh97.04087. PMID 15615256.

[pmid15233997-4] Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (August 2004). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.

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