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CREB3
| CREB3 |
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| | Pengidentifikasi |
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| Alias | CREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3 |
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| ID eksternal | OMIM: 606443 MGI: 99946 HomoloGene: 31375 GeneCards: CREB3 |
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| | Ontologi gen |
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| Fungsi molekuler | • DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• homodimerisasi protein
• protein dimerization activity
• cAMP response element binding protein binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• CCR1 chemokine receptor binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• chromatin binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
• GO:0001948, GO:0016582 Ikatan protein plasma
• cAMP response element binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Komponen seluler | • sitoplasma
• komponen integral membran
• nuclear body
• endoplasmic reticulum membrane
• membran
• integral component of endoplasmic reticulum membrane
• soma
• Retikulum endoplasma
• Inti sel
• sitosol
• Golgi membrane
• nucleoplasm
• badan Golgi
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| Proses biologis | • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
• GO:0009373 regulation of transcription, DNA-templated
• release from viral latency
• positive regulation of cell migration
• cytoplasmic sequestering of transcription factor
• negative regulation of cell cycle
• positive regulation of monocyte chemotaxis
• transcription, DNA-templated
• response to endoplasmic reticulum stress
• induction of positive chemotaxis
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• chemotaxis
• response to unfolded protein
• regulation of cell population proliferation
• regulation of cell growth
• establishment of viral latency
• positive regulation of deacetylase activity
• positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
• GO:0022415 viral process
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• positive regulation of defense response to virus by host
• positive regulation of calcium ion transport
• transcription by RNA polymerase II
• endoplasmic reticulum unfolded protein response
• regulation of apoptotic process
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| Sumber:Amigo / QuickGO |
| | Ortolog |
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| Spesies | Manusia | Tikus |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Lokasi (UCSC) | n/a | n/a |
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| Pencarian PubMed | [1] | [2] |
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| Wikidata | |
Cyclic AMP-responsive element-binding protein 3 (CREB3) adalah protein yang pada manusia dikodekan oleh gen CREB3.[3][4]
Gen ini mengkodekan faktor transkripsi yang merupakan anggota keluarga protein pengikat DNA leusin. Protein ini mengikat elemen responsif cAMP, palindrom oktamerik. Protein tersebut berinteraksi dengan faktor C1 sel inang, yang juga terkait dengan protein virus herpes simpleks (HSV) VP16 yang menginduksi transkripsi gen HSV. Protein dan VP16 ini mengikat situs yang sama pada faktor sel inang C1. Diperkirakan bahwa interaksi antara protein ini dan faktor C1 sel inang berperan dalam pembentukan latensi selama infeksi HSV. Varian transkrip tambahan telah diidentifikasi, tetapi validitas biologisnya belum ditentukan.[4]
Interaksi
CREB3 telah terbukti berinteraksi dengan Host cell factor C1.[5][6]
Lihat pula
Referensi
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol. 17 (9): 5117–26. doi:10.1128/MCB.17.9.5117. PMC 232362
 . PMID 9271389.
- ^ a b "Entrez Gene: CREB3 cAMP responsive element binding protein 3".
- ^ Lu, R; Yang P; Padmakumar S; Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. 72 (8): 6291–7. doi:10.1128/JVI.72.8.6291-6297.1998. ISSN 0022-538X. PMC 109766 . PMID 9658067.
- ^ Freiman, R N; Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754 . PMID 9389645.
Bacaan lanjutan
- Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMC 316754 . PMID 9389645.
- Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. 72 (8): 6291–7. doi:10.1128/JVI.72.8.6291-6297.1998. PMC 109766 . PMID 9658067.
- Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency". J. Virol. 74 (2): 934–43. doi:10.1128/JVI.74.2.934-943.2000. PMC 111614 . PMID 10623756.
- Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP". Mol. Cell. Biol. 20 (3): 919–28. doi:10.1128/MCB.20.3.919-928.2000. PMC 85209 . PMID 10629049.
- Jin DY, Wang HL, Zhou Y, et al. (2000). "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation". EMBO J. 19 (4): 729–40. doi:10.1093/emboj/19.4.729. PMC 305611 . PMID 10675342.
- Luciano RL, Wilson AC (2000). "N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10757–62. Bibcode:2000PNAS...9710757L. doi:10.1073/pnas.190062797. PMC 27096 . PMID 10984507.
- Raggo C, Rapin N, Stirling J, et al. (2002). "Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis". Mol. Cell. Biol. 22 (16): 5639–49. doi:10.1128/MCB.22.16.5639-5649.2002. PMC 133973 . PMID 12138176.
- Mahajan SS, Little MM, Vazquez R, Wilson AC (2003). "Interaction of HCF-1 with a cellular nuclear export factor". J. Biol. Chem. 277 (46): 44292–9. doi:10.1074/jbc.M205440200. PMC 4291127 . PMID 12235138.
- Luciano RL, Wilson AC (2002). "An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13403–8. Bibcode:2002PNAS...9913403L. doi:10.1073/pnas.202200399. PMC 129685 . PMID 12271126.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
- Ko J, Jang SW, Kim YS, et al. (2004). "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines". FASEB J. 18 (7): 890–2. doi:10.1096/fj.03-0867fje. PMID 15001559.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
- Misra V, Rapin N, Akhova O, et al. (2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman". J. Biol. Chem. 280 (15): 15257–66. doi:10.1074/jbc.M500728200 . PMID 15705566.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Liang G, Audas TE, Li Y, et al. (2007). "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element". Mol. Cell. Biol. 26 (21): 7999–8010. doi:10.1128/MCB.01046-06. PMC 1636730 . PMID 16940180.
- Blot G, Lopez-Vergès S, Treand C, et al. (2007). "Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR". J. Mol. Biol. 364 (5): 1034–47. doi:10.1016/j.jmb.2006.09.080. PMID 17054986.
- Jang SW, Kim YS, Lee YH, Ko J (2007). "Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines". J. Cell. Physiol. 211 (3): 630–7. doi:10.1002/jcp.20968. PMID 17192849.
- Jang SW, Kim YS, Kim YR, et al. (2007). "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1". J. Biol. Chem. 282 (15): 11092–100. doi:10.1074/jbc.M607962200 . PMID 17296613.
Pranala luar
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