zh HBP1

HMG盒转录因子1
HMG-box transcription factor 1
HMG盒转录因子1; HMG-box transcription factor 1
	PDB rendering based on 1v06.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2E6O, 3QVE
标识
代号	HBP1; FLJ16340
扩展标识	鼠基因：894659 同源基因：8171 GeneCards: HBP1 Gene
基因本体论描述
分子功能	· DNA binding; · RNA binding;
细胞成分	· nucleus;
生物过程	· transcription, DNA-dependent; · regulation of transcription, DNA-dependent; · cell cycle arrest; · Wnt receptor signaling pathway; · positive regulation of potassium ion transport;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	26959
Ensembl	ENSG00000105856
UniProt	O60381
mRNA序列	NM_001244262
蛋白序列	NP_001231191
基因位置	Chr 7:; 106.81 – 106.84 Mb
PubMed查询	[1]
	查; 论; 编;

HMG盒转录因子1（英語：HMG-box transcription factor 1，缩写为HBP1）是一种人类蛋白质^[1]。

相互作用

HBP1与SIN3A^[2]和视网膜母细胞瘤蛋白^[3]存在相互作用。

参考文献

^ Entrez Gene: HBP1 HMG-box transcription factor 1.
^ Swanson, Kurt A; Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat. Struct. Mol. Biol. (United States). Aug 2004, 11 (8): 738–46. ISSN 1545-9993. PMID 15235594. doi:10.1038/nsmb798.
^ Lavender, P; Vandel L, Bannister A J, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene (ENGLAND). Jun 1997, 14 (22): 2721–8. ISSN 0950-9232. PMID 9178770. doi:10.1038/sj.onc.1201243.

延伸阅读

Tevosian SG, Shih HH, Mendelson KG; et al. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.. Genes Dev. 1997, 11 (3): 383–96. PMID 9030690. doi:10.1101/gad.11.3.383.
Lavender P, Vandel L, Bannister AJ, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.. Oncogene. 1997, 14 (22): 2721–8. PMID 9178770. doi:10.1038/sj.onc.1201243.
Zhuma T, Tyrrell R, Sekkali B; et al. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J. 2000, 18 (22): 6396–406. PMC 1171702 . PMID 10562551. doi:10.1093/emboj/18.22.6396.
Lemercier C, Duncliffe K, Boibessot I; et al. Involvement of Retinoblastoma Protein and HBP1 in Histone H10 Gene Expression. Mol. Cell. Biol. 2000, 20 (18): 6627–37. PMC 86159 . PMID 10958660. doi:10.1128/MCB.20.18.6627-6637.2000.
Shih HH, Xiu M, Berasi SP; et al. HMG Box Transcriptional Repressor HBP1 Maintains a Proliferation Barrier in Differentiated Liver Tissue. Mol. Cell. Biol. 2001, 21 (17): 5723–32. PMC 87292 . PMID 11486012. doi:10.1128/MCB.21.17.5723-5732.2001.
Sampson EM, Haque ZK, Ku MC; et al. Negative regulation of the Wnt–β-catenin pathway by the transcriptional repressor HBP1. EMBO J. 2001, 20 (16): 4500–11. PMC 125566 . PMID 11500377. doi:10.1093/emboj/20.16.4500.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hillier LW, Fulton RS, Fulton LA; et al. The DNA sequence of human chromosome 7. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
de Chiara C, Kelly G, Frenkiel TA, Pastore A. Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1. J. Biomol. NMR. 2004, 28 (4): 411–2. PMID 14872137. doi:10.1023/B:JNMR.0000015367.92295.0f.
Berasi SP, Xiu M, Yee AS, Paulson KE. HBP1 Repression of the p47phox Gene: Cell Cycle Regulation via the NADPH Oxidase. Mol. Cell. Biol. 2004, 24 (7): 3011–24. PMC 371097 . PMID 15024088. doi:10.1128/MCB.24.7.3011-3024.2004.
Colland F, Jacq X, Trouplin V; et al. Functional Proteomics Mapping of a Human Signaling Pathway. Genome Res. 2004, 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Swanson KA, Knoepfler PS, Huang K; et al. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat. Struct. Mol. Biol. 2004, 11 (8): 738–46. PMID 15235594. doi:10.1038/nsmb798.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yao CJ, Works K, Romagnoli PA, Austin GE. Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. Leukemia. 2005, 19 (11): 1958–68. PMID 16179914. doi:10.1038/sj.leu.2403918.
Rual JF, Venkatesan K, Hao T; et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Sekkali B, Szabat E, Ktistaki E; et al. Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation. J. Immunol. 2005, 175 (8): 5203–12. PMID 16210625.
Kim J, Zhang X, Rieger-Christ KM; et al. Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1. J. Biol. Chem. 2006, 281 (16): 10865–75. PMID 16495219. doi:10.1074/jbc.M513378200.
Lim J, Hao T, Shaw C; et al. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006, 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
Zhang X, Kim J, Ruthazer R; et al. The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence. Mol. Cell. Biol. 2007, 26 (22): 8252–66. PMC 1636767 . PMID 16966377. doi:10.1128/MCB.00604-06.

外部链接

醫學主題詞表（MeSH）：HBP1+protein,+human

[entrez-1] Entrez Gene: HBP1 HMG-box transcription factor 1.

[pmid15235594-2] Swanson, Kurt A; Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat. Struct. Mol. Biol. (United States). Aug 2004, 11 (8): 738–46. ISSN 1545-9993. PMID 15235594. doi:10.1038/nsmb798.

[pmid9178770-3] Lavender, P; Vandel L, Bannister A J, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene (ENGLAND). Jun 1997, 14 (22): 2721–8. ISSN 0950-9232. PMID 9178770. doi:10.1038/sj.onc.1201243.

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