The solid dispersion system of meloxicam-hydroxypropyl methylcelluloce (HPMC) 6 centipoise (cps) had been studied. The solid dispersion system was prepared by solvation method with several combination of meloxicam and HPMC were 1:1, 1:3 and 1:5. The physical mixture of meloxicam and HPMC with similar composition were used as standard. The powder of solid dispersion system and physical mixture were evaluated by X-ray powder diffraction, thermal (DTA), SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type II apparatus. The result of X-ray powder diffraction analysis showed that the solid dispersion of  meloxicam with HPMC decreased the drug crystallinity. The endothermic peak of meloxicam from solid dispersion products shifted to lower temperature and peak intensity decreased significantly. X-ray powder diffraction and DTA indicated transformation of crystalline state of meloxicam to amorphous one by solid dispersion with HPMC. SEM results showed the solid dispersion of meloxicam and HPMC has agglomerates form. FT-IR spectra indicated no chemical interaction between meloxicam and HPMC in the solid dispersion. The highest in dissolution rate was observed with solid dispersion products of meloxicam and HPMC with ratio 1:5 (94,083 %) compared to pure meloxicam and its physical mixture.

Informasi yang terkait dengan Studi Sistem Dispersi Padat Meloksikam Menggunakan Hiroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS)

Studi Zhuang Studi Timur Tengah Studi Taurat Studi Korea Studi perdamaian dan konflik Studi hukum kritis Institut Studi Islam Darussalam Studi Alkitab Program studi Kawasan Studi Purba Mazhab Wales (studi keamanan) Pusat Studi Satwa Primata Lingkar Studi Teater dan Sastra Kampung Mazhab Paris (studi keamanan) Institut Kepausan untuk Studi Arab dan Islam Program Studi Teknik Arsitektur Universitas Kristen Petra Studi global Studi Iran Program Studi Teknik Mesin Universitas Kristen Petra Wes Studi Studi keamanan Kajian Islam Studi keamanan kritis Studi kasus Program Studi Teknik Informatika Univ…

ersitas Kristen Petra Studi biblika Program Studi Teknik Sipil Universitas Kristen Petra Studi internasional Lingkar studi Program Studi Teknik Industri Universitas Kristen Petra Studi kelayakan Studi terorisme kritis Lembaga Studi Sosial dan Agama Studi Abad Pertengahan Fakultas Ushuluddin Dan Studi Agama UIN Raden Intan Pusat Studi Air Power Indonesia Eksperimen pendahuluan Institut Studi Arus Informasi Institut Studi Islam Muhammadiyah Pacitan Studi genetika bangsa Bosniak Lingkar Studi Mahasiswa Marhaenis Akreditasi Universitas Indonesia Studi Karakter Petani (serial Van Gogh) Universitas Pamulang Jenjang Pendidikan dan Program Studi Universitas Indonesia Program Studi Psikologi Universitas Islam Negeri Walisongo Universitas Teramo Institut Transportasi dan Logistik Trisakti Institut Studi Lanjutan Institut Studi Perdamaian Pakistan Asosiasi Studi Kehidupan dan Sejarah Afrika Amerika Universitas Macerata Disiplin ilmiah Universitas Muhammadiyah Lamongan Pusat Studi dan Layanan Disabilitas Universitas Brawijaya Kajian longitudinal Universitas Kristen Petra Kelompok Kerja-Belajar di Prancis SOAS Universitas London Universitas Diponegoro Institut Internasional untuk Studi Strategi