In this study, we present the results of treatment of 224 patients with idiopathic thrombocytopenic purpura(ITP). In this study, we present the comparative results of treatment with inhalation and traditional methodby glucocorticoid hormones and spl?nectomy (SE). It was established that the usage of glucocorticosteroidhormones in the manner of cold doses inhalation was more effective in 87, (2%) of patients in comparisonwith traditional method of treatment – 75,(7%) and in this way the remission of disease approaches on6,3 days earlier. For the treatment of these patients we used splenectomyand created new approach to theoperation. This method, which was executed in the early post operational period, was more effective in 96,(9 %) of cases compared with traditional approach.