Shana O. Kelley

Shana O. Kelley
Alma materSeton Hall University BA (1994)
California Institute of Technology PhD (1999)
SpouseEdward H. Sargent
Scientific career
InstitutionsBoston College
University of Toronto
Northwestern University
Chan Zuckerberg Biohub
ThesisElectron transfer through the DNA double helix: spectroscopic and electrochemical studies (1999)
Doctoral advisorJacqueline Barton
Other academic advisorsPaul Schimmel
Websitekelleylaboratory.northwestern.edu

Shana O. Kelley is a scientist and Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. She is affiliated with Northwestern's International Institute for Nanotechnology[1] and was previously part of the University of Toronto's Faculty of Pharmacy and Faculty of Medicine. Kelley's research includes the development of new technologies for clinical diagnostics and drug delivery.[2] In 2023, she was chosen as president of Chicago's new Chan Zuckerberg Biohub.[3][4]

Education and training

Kelley received her BS from Seton Hall University in 1994. She pursued graduate studies in chemistry at the California Institute of Technology, where she worked with Jacqueline Barton. She graduated with her PhD in 1999 with a dissertation entitled Electron Transfer through the DNA Double Helix: Spectroscopic and Electrochemical Studies.[5]

From 1999 to 2000, Kelley was a NIH Postdoctoral Fellow at the Scripps Research Institute, where she worked with Paul Schimmel.[6][7]

Career

Kelley began her independent research career as an Assistant Professor in the Chemistry Department at Boston College in 2000. In 2006, she was promoted directly to the rank of Full Professor and in 2007, she joined the Leslie Dan Faculty of Pharmacy at the University of Toronto.[8] In August 2021, she joined Northwestern University's Departments of Chemistry and Biomedical Engineering as a named professor.[9][10] It was announced in March 2023 that she would head the new Chan Zuckerberg Biohub in Chicago, which will be a collaboration between Northwestern, University of Chicago, and University of Illinois at Urbana-Champaign.[3]

Kelley founded a university spin-off company named GeneOhm Sciences with her graduate advisor Jacqueline Barton. GeneOhm Sciences was based on a discovery that Kelley made during her graduate studies, where she developed a method to detect mutations in DNA by modifying the DNA strands and measuring their differing conductivity.[11][12][13] GeneOhm Sciences used Kelley's discovery to create a diagnostic test for antibiotic-resistant MRSA bacteria.[14] GeneOhm was acquired by Becton Dickinson in early 2006.[15] Kelley also founded the molecular diagnostics company Xagenic Inc.[16] In April 2023, she started a new company, CTRL Therapeutics, which aims to improve existing cell therapy in cancer treatment by focusing on the CTRL gene.[17]

Awards

Personal life

Kelley is married to fellow University of Toronto Professor Ted Sargent.[34][35] They met at a nanotechnology conference at UC Irvine, and have two children together.[36]

References

  1. ^ "Internationally renowned researchers Shana Kelley and Ted Sargent join Northwestern – Weinberg College News". news.weinberg.northwestern.edu. Retrieved August 24, 2021.
  2. ^ "Shana O. Kelley". University of Toronto.
  3. ^ a b Dolan, Kerry A. (March 2, 2023). "Exclusive: Mark Zuckerberg And Priscilla Chan On Their New 'Biohub' In Chicago And How They Plan To Spend Billions To Help Others Cure Or Manage Disease". Forbes. Retrieved April 24, 2023.
  4. ^ Chao, Julie (May 15, 2023). "High Risk, High Reward: Shana Kelley on Building a New Biohub". CZ Biohub. Retrieved June 22, 2023.
  5. ^ Kelley, Shana O. (1999). Electron transfer through the DNA double helix: spectroscopic and electrochemical studies. thesis.library.caltech.edu (phd). doi:10.7907/HZ7H-AD50. Retrieved November 14, 2018.
  6. ^ Kelley, Shana O.; Steinberg, Sergey V.; Schimmel, Paul (2000). "Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility". Nature Structural Biology. 7 (10): 862–865. doi:10.1038/79612. ISSN 1545-9985. PMID 11017193. S2CID 11745118.
  7. ^ Kelley, Shana O.; Steinberg, Sergey V.; Schimmel, Paul (April 6, 2001). "Fragile T-stem in Disease-associated Human Mitochondrial tRNA Sensitizes Structure to Local and Distant Mutations *". Journal of Biological Chemistry. 276 (14): 10607–10611. doi:10.1074/jbc.M008320200. ISSN 0021-9258. PMID 11110797.
  8. ^ a b c d e f g h "Shana Kelley – Division of the Vice-President & Provost". Retrieved July 10, 2021.
  9. ^ "Internationally renowned researchers Shana Kelley and Ted Sargent join Northwestern". Weinberg College of Arts & Sciences, Northwestern University. August 23, 2021. Retrieved April 24, 2023.
  10. ^ a b "Fall 2022 ACS Meeting Doolittle Award Awarded to Prof. Shana Olwyn Kelley". PMSE. October 18, 2022. Retrieved April 24, 2023.
  11. ^ Kelley, Shana O.; Jackson, Nicole M.; Hill, Michael G.; Barton, Jacqueline K. (1999). "Long-Range Electron Transfer through DNA Films". Angewandte Chemie International Edition. 38 (7): 941–945. doi:10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7. ISSN 1521-3773. PMID 29711858.
  12. ^ Kelley, S. (December 15, 1999). "Single-base mismatch detection based on charge transduction through DNA". Nucleic Acids Research. 27 (24): 4830–4837. doi:10.1093/nar/27.24.4830. ISSN 1362-4962. PMC 148785. PMID 10572185.
  13. ^ "Patent No. US 6,221,586 B1" (PDF).
  14. ^ "Shana Kelley on founding, developing life science startups". The Varsity. March 25, 2019. Retrieved July 10, 2021.
  15. ^ "BD Acquires GeneOhm Sciences for $230M in Bid to Bolster Infectious-Disease Play". GenomeWeb. Retrieved November 14, 2018.
  16. ^ "Shana Kelley: A quicker way to diagnose disease". Retrieved November 14, 2018.
  17. ^ Asplund, Jon (April 11, 2023). "Northwestern researcher spins out tumor-fighting therapy company". Chicago Business. Retrieved April 24, 2023.
  18. ^ "2008 – Canada's Top 40 Under 40".
  19. ^ "Innovator Under 35: Shana Kelley, 34". MIT Technology Review. Retrieved November 14, 2018.
  20. ^ Government of Canada, Natural Sciences and Engineering Research Council of Canada (June 28, 2016). "NSERC – E.W.R. Steacie – Shana Kelley". Natural Sciences and Engineering Research Council of Canada (NSERC). Retrieved July 10, 2021.
  21. ^ "Nanotechnology Now – Press Release: 2011 Steacie Prize awarded for nanotechnology-enabled disease diagnosis: Pharmacy's Shana Kelley third consecutive U of T professor to win prestigious science and engineering award". www.nanotech-now.com. Retrieved July 10, 2021.
  22. ^ "New Tools to Rapidly Diagnose Infections and Detect Antibiotic-Resistant Bacteria – Society for Laboratory Automation and Screening". September 24, 2020. Archived from the original on September 24, 2020. Retrieved July 10, 2021.
  23. ^ Government of Canada, Natural Sciences and Engineering Research Council of Canada (June 28, 2016). "NSERC – Brockhouse – Winners". Natural Sciences and Engineering Research Council of Canada (NSERC). Retrieved July 10, 2021.
  24. ^ "Shana Kelley Shana O. Kelley, Ph.D. To be Inducted into Medical and Biological Engineering Elite – AIMBE". Retrieved July 10, 2021.
  25. ^ Wang, Linda (May 15, 2017). "Inorganic award to Shana Kelley". cen.acs.org. Retrieved July 10, 2021.
  26. ^ "Somorjai Award". miller.berkeley.edu. Retrieved July 10, 2021.
  27. ^ "Rowland Institute Visiting Distinguished Scholar – Professor Shana Kelley". www2.rowland.harvard.edu. Retrieved July 10, 2021.
  28. ^ "2020 AFPC Award Winners | afpc". www.afpc.info. Retrieved July 10, 2021.
  29. ^ "PRESS RELEASE | THE RSC PRESENTS THE CLASS OF 2021 | The Royal Society of Canada". rsc-src.ca. September 7, 2021. Retrieved April 3, 2022.
  30. ^ "Ontario Newsroom". news.ontario.ca. Retrieved July 10, 2021.
  31. ^ "Shana Kelley Named Guggenheim Fellow". Robert R. McCormick School of Engineering and Applied Science. April 12, 2022. Retrieved April 12, 2022.
  32. ^ "Meet Our 2022 Fellows". John Simon Guggenheim Memorial Foundation. Retrieved April 12, 2022.
  33. ^ "New Members Elected in 2023". American Academy of Arts and Sciences. Retrieved April 24, 2023.
  34. ^ "Sargent wins Steacie Prize for outstanding young Canadian researcher". University of Toronto News. Retrieved June 2, 2021.
  35. ^ "Shana Kelley, Ted Sargent". The New York Times. July 30, 2006. ISSN 0362-4331. Retrieved June 2, 2021.
  36. ^ Nayyar, Anjum (February 13, 2012). "Campus couple balances challenges of work, home". University of Toronto News. Retrieved June 4, 2021.