Phosphoamidase

phosphoamidase
Identifiers
EC no.	3.9.1.1
CAS no.	9001-79-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphoamidase (EC 3.9.1.1) is an enzyme that catalyzes the chemical reaction

N-phosphocreatine + H₂O ${\displaystyle \rightleftharpoons }$ creatine + phosphate

Thus, the two substrates of this enzyme are N-phosphocreatine and H₂O, whereas its two products are creatine and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphorus-nitrogen bonds. The systematic name of this enzyme class is phosphamide hydrolase. This enzyme is also called creatine phosphatase.

References

• Parvin R, Smith RA (1969). "Phosphoramidates. V. Probable identity of rat liver microsomal glucose 6-phosphatase, phosphoramidase, and phosphoramidate-hexose phosphotransferase". Biochemistry. 8 (4): 1748–55. doi:10.1021/bi00832a058. PMID 4308726.
• Singer MF; Fruton JS (1957). "Some properties of beef spleen phosphoamidase". J. Biol. Chem. 229 (1): 111–119. doi:10.1016/S0021-9258(18)70599-1. PMID 13491564.
• Sundarajan TA; Sarma PS (1959). "Substrate specificity of phosphoprotein phosphatase from spleen". Biochem. J. 71 (3): 537–544. doi:10.1042/bj0710537. PMC 1196829. PMID 13638262.