Leucine 2,3-aminomutase

leucine 2,3-aminomutase
Identifiers
EC no.	5.4.3.7
CAS no.	59125-53-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a leucine 2,3-aminomutase (EC 5.4.3.7) is an enzyme that catalyzes the chemical reaction

(2S)-alpha-leucine ${\displaystyle \rightleftharpoons }$ (3R)-beta-leucine

Hence, this enzyme is responsible for the conversion of L-leucine to β-leucine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (2S)-alpha-leucine 2,3-aminomutase. This enzyme participates in valine, leucine and isoleucine degradation. It employs one cofactor, cobamide.

References

• Freer I, Pedrocchi-Fantoni G, Picken DJ, Overton KH (1981). "Stereochemistry of the leucine 2,3-aminomutase from tissue-cultures of Andrographis paniculata". Journal of the Chemical Society, Chemical Communications (3): 80–82. doi:10.1039/c39810000080.
• Poston JM (1976). "Leucine 2,3-aminomutase, an enzyme of leucine catabolism". J. Biol. Chem. 251 (7): 1859–63. PMID 1270414.
• Poston JM (1976). "Coenzyme B12-dependent enzymes in potatoes: leucine 2,3-aminomutase and methylmalonyl-CoA mutase". Phytochemistry. 17 (3): 401–402. doi:10.1016/S0031-9422(00)89324-3.