After graduating from high school in Buffalo Lake, Minnesota, Krampitz matriculated in 1927 at Macalester College, where he graduated in 1931 with a bachelor's degree with a joint major in biology and chemistry. From 1931 to 1938 he taught high school and occasionally worked at miscellaneous jobs. In 1938 he became a graduate student at Iowa State College (now named Iowa State University). There he did research on microbial metabolism and graduated in 1942 with a Ph.D. in microbiology.[2] His Ph.D. thesis The fixation of carbon dioxide in oxalacetic acid and its relationship to bacterial inspiration[3] was supervised by C. H. Werkman.[1] For the academic year 1942–1943 as a postdoc in D. W. Woolley's laboratory at the Rockefeller Institute, Krampitz did research on vitamin antagonists that occur in nature.[2] From 1943 to 1946 he was an assistant professor of bacteriology at Iowa State.[4]
In 1946 Krampitz became a member of the biochemistry department of Case Western Reserve University School of Medicine. There he was from 1946 to 1948 an associate professor in the biochemistry department and from 1948 to 1978 a full professor and director of the microbiology department (which was formed in 1948).[1] He did some research on penicillin's mode of action.[4] As director of the microbiology department, he hired a number of noteworthy faculty members, including L. Leon Campbell, Howard Gest, and Charles Yanofsky.[2] Krampitz, in a 1956 letter to Joshua Lederberg, proposed Yanofsky for the Eli Lilly and Company-Elanco Research Award, which Yanofsky received in 1959.[5]
Krampitz was one of the most important participants in the reorganization of Case Western Reserve's medical school curriculum. Traditionally, course material was taught by specific discipline (such as anatomy, immunology, toxicology, and so on) — in the new approach the courses were taught in terms of organ systems in integrated explanations. Clinical studies were introduced in the first year of medical school. Medical students were required to pursue research projects. This innovative approach significantly influenced medical schools in the United States.[2]
Krampitz's research involved the use of isotopes in the study of the carbon metabolism of bacteria,[4] until his research switched to biohydrogen in the context of the 1973 oil crisis.[6] In 1978 he resigned his positions and retired. He kept a small laboratory and visited it every day until he fell ill in the early 1990s.[2]
Krampitz, Lester O.; Greull, Gerhard; Miller, Charles S.; Bicking, John B.; Skeggs, Helen R.; Sprague, James M. (1958). "An Active Acetaldehyde-Thiamine Intermediate". Journal of the American Chemical Society. 80 (21): 5893–5894. doi:10.1021/ja01554a078.
^ abcdefgh"Lester Orville Krampitz 1909–1993 by Robert Hogg, Charles G. Miller, and C. Willard Shuster". Biographical Memoirs, National Academy of Sciences. Vol. 71. Washington, DC: The National Academies Press. 1997. pp. 97–108. doi:10.17226/5737. ISBN978-0-309-05738-7.
