Seitz did much of his early work in Fort Lee, New Jersey when many other early film studios in America's first motion picture industry were based there.[3][4][5] He was the director of more than one hundred films, the writer of more than thirty screenplays, and an actor in seven films. He worked at Columbia Pictures and at Metro-Goldwyn-Mayer where he directed eleven films in the Andy Hardy series of the 1930s & 1940s. He died in Hollywood, California in 1944. Although an acquaintance of the cinematographer John F. Seitz, they were not related. He was the father of George B. Seitz Jr., who was a writer/director active in the 1940s and 1950s in films and television.