The northern part of the regional unit, bordering Bulgaria, is very mountainous. The main mountain ranges are Orvilos (Bulgarian: Славянка - Slavyanka) in the northwest, Falakro in the north (at 2232m the highest point of the regional unit), the western Rhodope Mountains in the northeast (including mounts Frakto, Elatia, Koula etc.) and Menoikio in the southwest. The Nestos is the longest river, flowing in the northeast. The northern portion holds a unique treasure known as Karantere (or Forest of Elatia).
Drama is surrounded by the regional units of Xanthi to the east, Kavala to the south, Serres to the southwest and to the west, and the Bulgarian provinces of Blagoevgrad and Smolyan to the north. Arable lands are located in the southern and the westcentral portion of Drama.
The southern part mainly has a Mediterranean climate. The climate is more continental with cold winters in higher elevations and in the northern part.
Administration
The Drama regional unit is subdivided into 5 municipalities. These are (number as in the map in the infobox):[2]
As a part of the 2011 Kallikratis government reform, the former Drama Prefecture (Greek: Νομός Δράμας) was transformed into a regional unit within the East Macedonia and Thrace region. The prefecture had the same territory as the present regional unit. At the same time, the municipalities were reorganised, according to the table below.[2]
According to the 2011 census, the Drama regional unit had a population of 98,287, 11,666 more inhabitants than in the 2021 census.