Cobalt-factor II C20-methyltransferase

cobalt-factor II C20-methyltransferase
Identifiers
EC no.	2.1.1.151
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a cobalt-factor II C20-methyltransferase (EC 2.1.1.151) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + cobalt-factor II ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + cobalt-factor III

The two substrates of this enzyme are S-adenosyl methionine and cobalt-factor II; its two products are S-adenosylhomocysteine and cobalt-factor III.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase. This enzyme is also called CbiL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

• Cobalamin biosynthesis

References

• Spencer P, Stolowich NJ, Sumner LW, Scott AI (1998). "Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium". Biochemistry. 37 (42): 14917–27. doi:10.1021/bi981366f. PMID 9778368.