Aminopeptidase I

Aminopeptidase I
Identifiers
EC no.3.4.11.22
CAS no.9031-94-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Aminopeptidase I (EC 3.4.11.22, aminopeptidase III, aminopeptidase yscI, leucine aminopeptidase IV, yeast aminopeptidase I) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide.

Aminoacyl-arylamides are poor substrates

References

  1. ^ Johnson MJ (1941). "Isolation and properties of a pure yeast polypeptidase". J. Biol. Chem. 137 (2): 575–586. doi:10.1016/S0021-9258(19)56163-4.
  2. ^ Metz G, Röhm KH (May 1976). "Yeast aminopeptidase I. Chemical composition and catalytic properties". Biochimica et Biophysica Acta (BBA) - Enzymology. 429 (3): 933–49. doi:10.1016/0005-2744(76)90338-7. PMID 5147.
  3. ^ Chang YH, Smith JA (April 1989). "Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae". The Journal of Biological Chemistry. 264 (12): 6979–83. doi:10.1016/S0021-9258(18)83527-X. PMID 2651436.
  4. ^ Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ (March 1996). "Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I". The Journal of Cell Biology. 132 (6): 999–1010. doi:10.1083/jcb.132.6.999. PMC 2120762. PMID 8601598.