Alison R. H. Narayan

Alison R.H. Narayan
Born1984 (age 40–41)
NationalityAmerican
Alma mater
Scientific career
FieldsBiocatalysis, Organic chemistry
InstitutionsUniversity of Michigan - Life Sciences Institute
ThesisNew Reactions and Synthetic Strategies toward Indolizidine Alkaloids and Pallavicinia Diterpenes (2011)
Doctoral advisorRichmond Sarpong
Other academic advisorsDavid H. Sherman

Alison Rae Hardin Narayan (born 1984)[1] is an American chemist and the William R. Roush assistant professor in the Department of Chemistry at the University of Michigan College of Literature, Science, and the Arts.[2] Additionally, she is a research assistant professor at University of Michigan Life Sciences Institute.[3]

Early life and education

Narayan grew up in Cheboygan, Michigan graduating from high school in Frankenmuth. She completed her B.S. in chemistry at the University of Michigan in 2006. During her bachelor's degree, she carried out research under the supervision of John P. Wolfe on palladium-catalyzed methodology for the synthesis of substituted tetrahydrofuran rings.[4] Narayan completed her Ph.D. in organic chemistry in 2011 with Richmond Sarpong at the University of California, Berkeley, with a thesis entitled "New Reactions and Synthetic Strategies toward Indolizidine Alkaloids and Pallavicinia Diterpenes".[5][6][7] In 2011, Narayan returned to the University of Michigan as a postdoctoral fellow in David Sherman's lab.[8] During her postdoc, she engineered cytochrome P450 enzymes to perform C-H functionalization in non-native substrates.[9][10][11] In 2015, Narayan joined the Department of Chemistry and the Life Sciences Institute at the University of Michigan as an assistant professor.[12]

Research

The Narayan lab focuses on identifying and characterizing enzymes from various microorganisms that can catalyze chemical reactions that are challenging to reproduce synthetically. These biocatalysts can be employed to create various chemicals for pharmaceutical or other purposes.[9][13]

Awards and honors

Narayan has received numerous awards and honors including:

Key publications

  • Baker Dockrey, S. A. and Narayan, A. R. H. “Flavin-dependent biocatalysts in synthesis” Tetrahedron 2019 doi:10.1016/j.tet.2019.01.008 (Special Issue on Biocatalysis in Organic Synthesis).
  • Lukowski, A. L.. and Narayan, A. R. H. “Natural voltage-gated sodium channel ligands: Biosynthesis and biology” ChemBioChem 2019 doi:10.1002/cbic.201800754 (Special Issue: New Talent).
  • Benítez, Attabey Rodríguez; Tweedy, Sara; Dockrey, Summer A. Baker; Lukowski, April L.; Wymore, Troy; Khare, Dheeraj; Brooks L. Charles III; Smith Janet L.; Narayan Alison R.H. (2018): Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization. ChemRxiv. Preprint. doi:10.26434/chemrxiv.7297766.v1
  • Baker Dockrey, S. A.; Doyon, T. J.; Perkins, J. C.; Narayan, A. R. H. “Whole-cell biocatalysis platform for gram-scale oxidative dearomatization of phenols”Chem. Biol. Drug Des. 2018 doi:10.1111/cbdd.13443
  • Lukowski, A. L.; Ellinwood, D. C.; Hinze, M. E.; DeLuca, R. J.; Du Bois, J.; Hall, S.; Narayan, A. R. H. "C–H hydroxylation in paralytic shellfish toxin biosynthesis" J. Am. Chem. Soc., 2018, 140 (37), 11863–11869 doi:10.1021/jacs.8b08901
  • Chun, S. W.; Hinze, M. E.; Skiba, M. A.; Narayan, A. R. H. "Chemistry of a unique polyketide-like synthase" J. Am. Chem. Soc. 2018, 140, 2430–2433. doi:10.1021/jacs.7b13297
  • Baker Dockrey, S. A.; Lukowski, A. L.; Becker, M. R.; Narayan, A. R. H. “Biocatalytic site- and enantioselective oxidative dearomatization of phenols” Nature Chem. 2018, 10, 119–125. doi:10.1038/nchem.2879

Mentored Key Publications

  • “Enzymatic Hydroxylation of an Unactivated Methylene C–H Bond Guided by Molecular Dynamics Simulations” (Nat. Chem. 2015, DOI: 10.1038/nchem.2285)[18]
  • “Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation” (J. Am. Chem. Soc. 2014, DOI: 10.1021/ja5016052) [10]
  • “Indolizinones as Synthetic Scaffolds: Fundamental Reactivity and the Relay of Stereochemical Information” (Org. Biomol. Chem. 2012, DOI: 10.1039/clob06423a)[7]

References

  1. ^ "Alison Rae-Hardin Narayan from Ann Arbor, Michigan". voterrecords.com. Retrieved 2019-01-27.
  2. ^ "Alison Narayan". University of Michigan. Retrieved 22 February 2019.
  3. ^ "Alison Narayan Lab". University of Michigan. 21 February 2018. Retrieved 22 February 2019.
  4. ^ Hay, Michael B.; Hardin, Alison R.; Wolfe, John P. (2005). "Palladium-Catalyzed Synthesis of Tetrahydrofurans from γ-Hydroxy Terminal Alkenes: Scope, Limitations, and Stereoselectivity". The Journal of Organic Chemistry. 70 (8): 3099–3107. doi:10.1021/jo050022+. ISSN 0022-3263. PMC 2700004. PMID 15822970.
  5. ^ Narayan, Alison Rae Hardin (2011). New Reactions and Synthetic Strategies toward Indolizidine Alkaloids and Pallavicinia Diterpenes (Thesis). UC Berkeley.
  6. ^ "The Sarpong Group Homepage". Synthetic organic chemistry lab at UC Berkeley. Archived from the original on 2020-03-31. Retrieved 2020-03-31.
  7. ^ a b Sarpong, Richmond; Narayan, Alison R. Hardin (2012-01-07). "Indolizinones as synthetic scaffolds: fundamental reactivity and the relay of stereochemical information". Organic & Biomolecular Chemistry. 10 (1): 70–78. doi:10.1039/C1OB06423A. ISSN 1477-0539. PMC 3342682. PMID 22072189.
  8. ^ "Alumni". nsf-cchf.com. Retrieved 2019-01-27.
  9. ^ a b c "C&EN's Talented 12". Talented 12. 2016-08-21. Retrieved 2019-01-27.
  10. ^ a b Negretti, Solymar; Narayan, Alison R. H.; Chiou, Karoline C.; Kells, Petrea M.; Stachowski, Jessica L.; Hansen, Douglas A.; Podust, Larissa M.; Montgomery, John; Sherman, David H. (2014-04-02). "Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation". Journal of the American Chemical Society. 136 (13): 4901–4904. doi:10.1021/ja5016052. ISSN 0002-7863. PMC 4012894. PMID 24627965.
  11. ^ Narayan, Alison R. H.; Jiménez-Osés, Gonzalo; Liu, Peng; Negretti, Solymar; Zhao, Wanxiang; Gilbert, Michael M.; Ramabhadran, Raghunath O.; Yang, Yun-Fang; Furan, Lawrence R.; Li, Zhe; Podust, Larissa M. (2015). "Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations". Nature Chemistry. 7 (8): 653–660. Bibcode:2015NatCh...7..653N. doi:10.1038/nchem.2285. ISSN 1755-4349. PMC 4518477. PMID 26201742.
  12. ^ "A year in the life of a new professor". cen.acs.org. Retrieved 2019-01-27.
  13. ^ "How bacteria build a deadly toxin". Nature. 554 (7693): 407. 2018-02-19. Bibcode:2018Natur.554U.407.. doi:10.1038/d41586-018-02199-4. PMID 32094965.
  14. ^ "2019 Awardees - Thieme Chemistry - Georg Thieme Verlag". Thieme. Retrieved 2019-01-27.
  15. ^ "RCSA Names Two Dozen 2019 Cottrell Scholars". Research Corporation for Science Advancement. Retrieved 2019-02-11.
  16. ^ "2019 Fellows". sloan.org. Archived from the original on 2019-02-20. Retrieved 2019-02-19.
  17. ^ "2020 Camille Dreyfus Teacher-Scholar Awards". Dreyfus Foundation. 2020-04-27. Retrieved 2021-06-10.
  18. ^ Sherman, David H.; Houk, K. N.; Montgomery, John; Podust, Larissa M.; Li, Zhe; Furan, Lawrence R.; Yun-Fang Yang; Ramabhadran, Raghunath O.; Gilbert, Michael M. (August 2015). "Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations". Nature Chemistry. 7 (8): 653–660. Bibcode:2015NatCh...7..653N. doi:10.1038/nchem.2285. ISSN 1755-4349. PMC 4518477. PMID 26201742.