Aldehyde dehydrogenase 9 family, member A1

ALDH9A1
Identifiers
Aliases	ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH
External IDs	OMIM: 602733; MGI: 1861622; HomoloGene: 55483; GeneCards: ALDH9A1; OMA:ALDH9A1 - orthologs
EC number	1.2.1.3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.1 Start 165,662,216 bp[1] End 165,698,562 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.3 Start 167,177,560 bp[2] End 167,196,101 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex salivary gland minor salivary glands mucosa of esophagus left lobe of thyroid gland right lobe of thyroid gland liver corpus callosum Top expressed in left lobe of liver retinal pigment epithelium Paneth cell crypt of lieberkuhn of small intestine human kidney migratory enteric neural crest cell ciliary body jejunum ileum decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aldehyde dehydrogenase (NAD+) activity oxidoreductase activity aminobutyraldehyde dehydrogenase activity 1-pyrroline dehydrogenase activity 4-trimethylammoniobutyraldehyde dehydrogenase activity 3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Cellular component cytoplasm extracellular exosome cytosol Biological process cellular aldehyde metabolic process hormone metabolic process metabolism neurotransmitter biosynthetic process carnitine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 223 56752 Ensembl ENSG00000143149 ENSMUSG00000026687 UniProt P49189 Q9JLJ2 RefSeq (mRNA) NM_000696 NM_001365774 NM_019993 RefSeq (protein) NP_000687 NP_001352703 NP_064377 NP_001389759 NP_001389768 NP_001389769 NP_001389773 NP_001389774 NP_001389775 NP_001392024 Location (UCSC) Chr 1: 165.66 – 165.7 Mb Chr 1: 167.18 – 167.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[5][6][7]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde (GABAL) and other amino aldehydes. The enzyme catalyzes the dehydrogenation of GABAL to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143149 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026687 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751. S2CID 26773065.
6. Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
7. "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

• Human ALDH9A1 genome location and ALDH9A1 gene details page in the UCSC Genome Browser.

Further reading

• Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. doi:10.1016/S0021-9258(18)83802-9. PMID 2925663.
• Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
• Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. doi:10.1042/bj3160317. PMC 1217341. PMID 8645224.
• Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
• Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
• Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142. S2CID 35621262.