3-demethylubiquinone-9 3-O-methyltransferase

3-demethylubiquinone-9 3-O-methyltransferase
Identifiers
EC no.	2.1.1.64
CAS no.	63774-48-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-demethylubiquinone-9 3-O-methyltransferase (EC 2.1.1.64) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3-demethylubiquinone-9 ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + ubiquinone-9

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-demethylubiquinone-9, whereas its two products are S-adenosylhomocysteine and ubiquinone-9.

This enzyme participates in ubiquinone biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1, 4-benzoquinone 3-O-methyltransferase. Other names in common use include 5-demethylubiquinone-9 methyltransferase, OMHMB-methyltransferase, 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone, methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-, and 1,4-benzoquinone-O-methyltransferase.

References

• Houser RM, Olson RE (June 1977). "5-demethylubiquinone-9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization". The Journal of Biological Chemistry. 252 (12): 4017–21. PMID 863914.
• Leppik RA, Stroobant P, Shineberg B, Young IG, Gibson F (March 1976). "Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase". Biochimica et Biophysica Acta (BBA) - General Subjects. 428 (1): 146–56. doi:10.1016/0304-4165(76)90116-1. PMID 769831.