Lumefantrin

Lumefantrin
Nama sistematis (IUPAC)
	2-(Dibutilamino)-1-[(9Z)-2,7-dikloro-9-(4-klorobenzilidena)-9H-fluoren-4-il]etanol
Data klinis
AHFS/Drugs.com	International Drug Names
MedlinePlus	a609024
Kat. kehamilan	?
Status hukum	?
Rute	Oral
Pengenal
Nomor CAS	82186-77-4
Kode ATC	P01BF01 (kombinasi dengan artemeter)
PubChem	CID 6437380
DrugBank	DB06708
ChemSpider	4941944
UNII	F38R0JR742
KEGG	D03821
ChEBI	CHEBI:156095
ChEMBL	CHEMBL38827
Data kimia
Rumus	C30H32Cl3NO
SMILES	eMolecules & PubChem
	InChI InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- ; Key:DYLGFOYVTXJFJP-MYYYXRDXSA-N ;
Data fisik
Titik lebur	130–132 °C (266–270 °F)

Lumefantrin atau benflumetol adalah obat antimalaria. Obat ini hanya digunakan dalam kombinasi dengan artemeter. Istilah "ko-artemeter" terkadang digunakan untuk menggambarkan kombinasi ini.^[1] Lumefantrin memiliki waktu paruh yang jauh lebih panjang dibandingkan dengan artemeter, dan oleh karena itu dianggap dapat membersihkan parasit sisa yang tersisa setelah pengobatan kombinasi.^[2]

Lumefantrin bersama dengan pironaridin dan naftokuin, disintesis selama upaya penelitian obat antimalaria Proyek 523 Cina yang dimulai pada tahun 1967; semua senyawa ini digunakan dalam terapi antimalaria kombinasi.^[3]^[4]^[5]

Referensi

^ Toovey S, Jamieson A, Nettleton G (August 2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease. 1 (3): 177–179. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.
^ White NJ, van Vugt M, Ezzet F (August 1999). "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. PMID 10496300.
^ Cui L, Su XZ (October 2009). "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-Infective Therapy. 7 (8): 999–1013. doi:10.1586/eri.09.68. PMC 2778258 . PMID 19803708.
^ Benjamin J, Moore B, Lee ST, Senn M, Griffin S, Lautu D, et al. (May 2012). "Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study". Antimicrobial Agents and Chemotherapy. 56 (5): 2465–2471. doi:10.1128/AAC.06248-11. PMC 3346652 . PMID 22330921.
^ Laman M, Moore BR, Benjamin JM, Yadi G, Bona C, Warrel J, et al. (December 2014). "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLOS Medicine. 11 (12): e1001773. doi:10.1371/journal.pmed.1001773 . PMC 4280121 . PMID 25549086.

[pmid17291911-1] Toovey S, Jamieson A, Nettleton G (August 2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease. 1 (3): 177–179. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.

[Whitevan_Vugt1999-2] White NJ, van Vugt M, Ezzet F (August 1999). "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. PMID 10496300.

[cui-3] Cui L, Su XZ (October 2009). "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-Infective Therapy. 7 (8): 999–1013. doi:10.1586/eri.09.68. PMC 2778258 . PMID 19803708.

[4] Benjamin J, Moore B, Lee ST, Senn M, Griffin S, Lautu D, et al. (May 2012). "Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study". Antimicrobial Agents and Chemotherapy. 56 (5): 2465–2471. doi:10.1128/AAC.06248-11. PMC 3346652 . PMID 22330921.

[5] Laman M, Moore BR, Benjamin JM, Yadi G, Bona C, Warrel J, et al. (December 2014). "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLOS Medicine. 11 (12): e1001773. doi:10.1371/journal.pmed.1001773 . PMC 4280121 . PMID 25549086.

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[2]

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Lumefantrin

Referensi

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